A review of Moroccan medicinal plants used in the treatment of inflammation

Aziz ZOUHRI; Yahya EL-MERNISSI; Naoual EL MENYIY; Toufik BOUDDINE; Nora MIR; Kamal EL AISSAOUI; Hassan AMHAMDI; Abdelhay ELHARRAK; Lhoussain HAJJI

doi:10.55779/nsb15111414

Authors

Aziz ZOUHRI Moulay Ismail University, Faculty of Sciences, Bioactives and Environmental Health Laboratory, Meknes B.P. 11201; National Agency for Medicinal and Aromatic Plants, Laboratory of Pharmacology, Taounate 34025 (MA)
Yahya EL-MERNISSI Abdelmalek Essaadi University, Applied Chemistry Team, Faculty of Science and Techniques, Al Hoceima 32003 (MA)
Naoual EL MENYIY National Agency for Medicinal and Aromatic Plants, Laboratory of Pharmacology, Taounate 34025 (MA)
Toufik BOUDDINE Moulay Ismail University, Faculty of Sciences, Bioactives and Environmental Health Laboratory, Meknes B.P. 11201 (MA)
Nora MIR Moulay Ismail University, Faculty of Sciences, Bioactives and Environmental Health Laboratory, Meknes B.P. 11201 (MA)
Kamal EL AISSAOUI Translation, Dialog of Civilisations and Arbitration, School of Arts and Humanities, Meknes N13 (MA)
Hassan AMHAMDI Abdelmalek Essaadi University, Applied Chemistry Team, Faculty of Science and Techniques, Al Hoceima 32003 (MA)
Abdelhay ELHARRAK Moulay Ismail University, Faculty of Sciences, Bioactives and Environmental Health Laboratory, Meknes B.P. 11201 (MA)
Lhoussain HAJJI Moulay Ismail University, Faculty of Sciences, Bioactives and Environmental Health Laboratory, Meknes B.P. 11201 (MA)

DOI:

https://doi.org/10.55779/nsb15111414

Keywords:

anti-inflammatory, inflammation, Moroccan, medicinal plants, systematic review, traditional medicine

Abstract

Inflammation is a mechanism that occurs against aggressive agents such as infections, wounds, pollens, autoimmune diseases, and tissue damage. Morocco has traditionally used herbal remedies to treat many illnesses, including inflammation. The objective of this study was to describe the Moroccan medicinal plants used in inflammation treatment. This systematic review examines ethnobotanical studies published in English and French in the literature as well as the pharmacological studies that assess anti-inflammatory activity in vitro and in vivo, from databases (Scopus, Web of Science, Science Direct, and Springer). The research was carried out until August 2021. In ethnobotanical surveys, 100 medicinal plants were identified, which belonged to 52 families of which the most often cited are Lamiaceae with 18 species, followed by Apiaceae (13 species) and Asteraceae (10 species). The most used plants to treat inflammation in Morocco are: Coriandrum sativum L, Caralluma europaea (Guss.) Nebr., Opuntia ficus-indica (L.) Mill., Capparis spinosa L., Anacyclus pyrethrum (L.) Lag, Ajuga iva (L.) Schreb., Thymus atlanticus (Ball) Pau, Thymus saturejoides Coss, Thymus zygis L., Lawsonia isermis L. and Rosmarinus officinalis L. This review highlighted Moroccan medicinal plants used in traditional medicine to treat inflammation. Many of this plant species require additional pharmacological, and clinical studies to verify which plants are effective in treating inflammation.

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References

Abbas Zaidi SM, Pathan SA, Singh S, Jamil S, Ahmad FJ, Khar RK (2013). Anticonvulsant, anxiolytic and neurotoxicity profile of aqarqarha (Anacyclus pyrethrum) DC (Compositae) root ethanolic extract. Pharmacology and Pharmacy 04(07):535-541. https://doi.org/10.4236/pp.2013.47077

Abdalla AN, Shaheen U, Abdallah QMA, Flamini G, Bkhaitan MM, Abdelhady MIS, Ascrizzi R, Bader A (2020). Proapoptotic activity of Achillea membranacea essential oil and its major constituent 1,8-Cineole against A2780 ovarian cancer cells. Molecules 25(7):1582. https://doi.org/10.3390/molecules25071582

Abdelli W, Bahri F, Romane A, Höferl M, Wanner J, Schmidt E, Jirovetz L (2017). Chemical composition and anti-inflammatory activity of Algerian Thymus vulgaris essential oil. Natural Product Communications 12(4):1934578X1701200. https://doi.org/10.1177/1934578X1701200435

Adnan M, Jan S, Mussarat S, Tariq A, Begum S, Afroz A, Shinwari ZK (2014). A review on ethnobotany, phytochemistry and pharmacology of plant genus Caralluma R. Br. Journal of Pharmacy and Pharmacology 66(10):1351-1368. https://doi.org/10.1111/jphp.12265

Ajebli M, Zair T, Eddouks M (2017). Étude ethnobotanique, phytochimique et évaluation de l ’ activité antibactérienne des fruits de Pimpinella anisum de diverses zones de culture au Maroc. https://doi.org/10.1007/s10298-017-1133-4

Alimi H, Hfaiedh N, Bouoni Z, Hfaiedh M, Sakly M, Zourgui L, Rhouma KB (2010). Antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis root extract in rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 17(14):1120-1126. https://doi.org/10.1016/j.phymed.2010.05.001

Amezouar F, Badri W, Hsaine M, Bourhim N, Fougrach H (2013). Évaluation des activités antioxydante et anti-inflammatoire de Erica arborea L. du Maroc. Pathologie Biologie 61(6):254-258. https://doi.org/10.1016/j.patbio.2013.03.005

Amrati FE-Z, Bourhia M, Saghrouchni H, Slighoua M, Grafov A, Ullah R, … Bousta D (2021). Caralluma europaea (Guss.) N.E.Br.: Anti-inflammatory, antifungal, and antibacterial activities against nosocomial antibiotic-resistant microbes of chemically characterized fractions. Molecules 26(3):636. https://doi.org/10.3390/molecules26030636

Bachar M, ElYacoubi H, Zidane L, Rochdi A (2021). Ethnomedicinal and traditional phytotherapeutic plants used in Bouhachem Natural Regional Park (Rif of Morocco): Case of Bni-Leit and Al-Oued districts. Journal of Pharmacy and Pharmacognosy Research 9(3):284-312.

Bakırel T, Bakırel U, Keleş OÜ, Ülgen SG, Yardibi H (2008). In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. Journal of Ethnopharmacology 116(1):64-73. https://doi.org/10.1016/j.jep.2007.10.039

Bellakhdar J (1997). La Pharmacopée Marocaine Traditionnelle: Médecine Arabe Ancienne Et Savoirs Populaires (1st ed.). Ibis Press.

Bellakhdar J, Claisse R, Fleurentin J, Younos C (1991). Repertory of standard herbal drugs in the Moroccan pharmacopoea. Journal of Ethnopharmacology 35(2):123-143. https://doi.org/10.1016/0378-8741(91)90064-k

Benayad Z, Martinez-Villaluenga C, Frias J, Gomez-Cordoves C, Es-Safi NE (2014). Phenolic composition, antioxidant and anti-inflammatory activities of extracts from Moroccan Opuntia ficus-indica flowers obtained by different extraction methods. Industrial Crops and Products 62:412-420. https://doi.org/10.1016/j.indcrop.2014.08.046

Bendif H, Boudjeniba M, Djamel Miara M, Biqiku L, Bramucci M, Caprioli G, … Maggi F (2017). Rosmarinus eriocalyx: An alternative to Rosmarinus officinalis as a source of antioxidant compounds. Food Chemistry 218:78-88. https://doi.org/10.1016/j.foodchem.2016.09.063

Bendjeddou D, Lalaoui K, Satta D (2003). Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis. Journal of Ethnopharmacology 88(2-3):155-160. https://doi.org/10.1016/S0378-8741(03)00226-5

Berkiks I, Boulbaroud S, Garcia-Segura LM, Mesfioui A, Ouichou A, Mouden S, … El hessni A (2018). Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats. Biomedicine & Pharmacotherapy 99:655-663. https://doi.org/10.1016/j.biopha.2018.01.125

Boualam K, Ndiaye B, Harhar H, Tabyaoui M, Ayessou N, Taghzouti K (2021). Study of the phytochemical composition, the antioxidant and the anti-inflammatory effects of two sub-Saharan plants: Piliostigma reticulatum and Piliostigma thonningii. Advances in Pharmacological and Pharmaceutical Sciences 2021:1-8. https://doi.org/10.1155/2021/5549478

Boufous H, Marhoume F, Chait A, Bagri A (2017). Ethnopharmacological survey of medicinal plants with hallucinogenic effect and used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora “Morocco.” Journal of Intercultural Ethnopharmacology 6(4):342-350. https://doi.org/10.5455/jice.20170721062527

Bouhlali E dine T, El Hilaly J, Ennassir J, Benlyas M, Alem C, … Filali-Zegzouti Y (2018). Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties. Journal of King Saud University - Science 30(4):519-526. https://doi.org/10.1016/j.jksus.2017.08.011

Bouhlali E dine T, Hmidan A, Bourkhis B, Khouya T, Ramchoun M, Filali-Zegzouti Y, Alem C (2020). Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties. Heliyon 6(2):e03436. https://doi.org/10.1016/j.heliyon.2020.e03436

Bouhlali E dine T, Sellam K, Bammou M, Alem C, Filali-Zehzouti Y (2016). In vitro antioxidant and anti-inflammatory properties of selected moroccan medicinal plants. Journal of Applied Pharmaceutical Science 6(5):156-162. https://doi.org/10.7324/JAPS.2016.60525

Bouhlali E, Sellam K, Bammou M, Alem C, Filali-Zehzouti Y (2016). In vitro antioxidant and anti-inflammatory properties of selected Moroccan medicinal plants. Journal of Applied Pharmaceutical Science 156-162. https://doi.org/10.7324/JAPS.2016.60525

Bounihi A, Hajjaj G, Alnamer R, Cherrah Y, Zellou A (2013). In vivo Potential anti-inflammatory activity of Melissa officinalis L. essential oil. Advances in Pharmacological Sciences 2013:1-7. https://doi.org/10.1155/2013/101759

Bouyahya A, Abrini J, Et-Touys A, Bakri Y, Dakka N (2017). Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. European Journal of Integrative Medicine 13:9-25. https://doi.org/10.1016/j.eujim.2017.06.004

Bouyahya A, El Omari N, Belmehdi O, Lagrouh F, El Jemli M, Marmouzi I, … Dakka N (2021). Pharmacological investigation of Ajuga iva essential oils collected at three phenological stages. Flavour and Fragrance Journal 36(1):75-83. https://doi.org/10.1002/ffj.3618

Bouyahya A, El Omari N, Elmenyiy N, Guaouguaou F-E, Balahbib A, El-Shazly M, Chamkhi I (2020). Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.) schreb. Journal of Ethnopharmacology 258:112875. https://doi.org/10.1016/j.jep.2020.112875

Bribi N, Algieri F, Rodriguez-Nogales A, Garrido-Mesa J, Vezza T, Maiza F, … Galvez J (2015). Antinociceptive and anti-inflammatory effects of total alkaloid extract from Fumaria capreolata. Evidence-Based Complementary and Alternative Medicine 2015:1-7. https://doi.org/10.1155/2015/736895

Chaachouay N, Benkhnigue O, Douira A, Zidane L (2021). Poisonous medicinal plants used in the popular pharmacopoeia of the Rif, northern Morocco. Toxicon 189:24-32. https://doi.org/10.1016/j.toxicon.2020.10.028

Chaachouay N, Douira A, Zidane L (2022). Herbal medicine used in the treatment of human diseases in the Rif, Northern Morocco. Arabian Journal for Science and Engineering 47(1):131-153. https://doi.org/10.1007/s13369-021-05501-1

Chadon Alphonsine Assemian IC, Bouyahya A, Dakka N, Bakri Y (2019). Garcinia mangostana leaf extracts from ivory coast possess remarkable antioxidant, anti-inflammatory, and cytotoxicological properties. Biomedical and Pharmacology Journal 12(2):571-578. https://doi.org/10.13005/bpj/1676

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9(6):7204-7218. https://doi.org/10.18632/oncotarget.23208

Chithra V, Leelamma S (1999). Coriandrum sativum — mechanism of hypoglycemic action. Food Chemistry 67(3):229-231. https://doi.org/10.1016/S0308-8146(99)00113-2

D’Aquino S, Chessa I, Inglese P, Liguori G, Barbera G, Ochoa MJ, Satta D, Palma A (2017). Increasing cold tolerance of cactus pear fruit by high-temperature conditioning and film wrapping. Food and Bioprocess Technology 10(8):1466-1478. https://doi.org/10.1007/s11947-017-1917-0

de Almeida Melo E, Mancini Filho J, Barbosa Guerra N (2005). Characterization of antioxidant compounds in aqueous coriander extract (Coriandrum sativum L.). LWT - Food Science and Technology 38(1):15-19. https://doi.org/10.1016/j.lwt.2004.03.011

de Melo GAN, Grespan R, Fonseca JP, Farinha TO, Silva EL, Romero AL, Bersani-Amado CA, Cuman RKN (2011). Rosmarinus officinalis L. essential oil inhibits in vivo and in vitro leukocyte migration. Journal of Medicinal Food 14(9):944-946. https://doi.org/10.1089/jmf.2010.0159

Derouich M, Bouhlali EDT, Hmidani A, Bammou M, Bourkhis B, Sellam K, Alem C (2020). Assessment of total polyphenols, flavonoids and anti-inflammatory potential of three Apiaceae species grown in the Southeast of Morocco. Scientific African 9:e00507. https://doi.org/10.1016/j.sciaf.2020.e00507

Doudach L, Meddah B, Alnamer R, Chibani F, Cherrah Y (2012). In vitro antibacterial activity of the methanolic and aqueous extracts of anacyclus pyrethrum used in Moroccan traditional medicine. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3):402-405.

Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M (2019). Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi Journal of Biological Sciences 26(6):1171-1178. https://doi.org/10.1016/j.sjbs.2018.05.028

Eddouks M, Ajebli M, Hebi M (2017). Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco. Journal of Ethnopharmacology 198:516-530. https://doi.org/10.1016/j.jep.2016.12.017

Eidi A, Eidi M (2009). Antidiabetic effects of sage (Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 3(1):40-44. https://doi.org/10.1016/j.dsx.2008.10.007

El-Hilaly J, Hmammouchi M, Lyoussi B (2003). Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). Journal of Ethnopharmacology 86(2-3):149-158. https://doi.org/10.1016/S0378-8741(03)00012-6

El-Hilaly J, Lyoussi B, Wibo M, Morel N (2004). Vasorelaxant effect of the aqueous extract of Ajuga iva in rat aorta. Journal of Ethnopharmacology 93(1):69-74. https://doi.org/10.1016/j.jep.2004.03.020

El-mekkawy S, Shahat AA, Alqahtani AS, Alsaid MS, Abdelfattah MAO, Ullah R, … Sobeh M (2020). A polyphenols-rich extract from Moricandia sinaica Boiss. exhibits analgesic, anti-inflammatory and antipyretic activities in vivo. Molecules 25(21):5049. https://doi.org/10.3390/molecules25215049

El Azhary K, Tahiri Jouti N, El Khachibi M, Moutia M, Tabyaoui I, El Hou A, … Badou A (2017). Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression. BMC Complementary and Alternative Medicine 17(1):81. https://doi.org/10.1186/s12906-017-1569-7

El Hachimi F, Alfaiz C, Bendriss A, Cherrah Y, Alaoui K (2017). Activité anti-inflammatoire de l’huile des graines de Zizyphus lotus (L.) Desf. Phytothérapie 15(3):147-154. https://doi.org/10.1007/s10298-016-1056-1

El Hamsas El Youbi A, El Mansouri L, Boukhira S, Daoudi A, Bousta D (2016). In vivo anti-inflammatory and analgesic effects of aqueous extract of Cistus ladanifer L. from Morocco. American Journal of Therapeutics 23(6):e1554-e1559. https://doi.org/10.1097/MJT.0000000000000419

El Jemli M, Kamal R, Marmouzi I, Doukkali Z, Bouidida EH, Touati D, … Alaoui K (2017). Chemical composition, acute toxicity, antioxidant and anti-inflammatory activities of Moroccan Tetraclinis articulata L. Journal of Traditional and Complementary Medicine 7(3):281-287. https://doi.org/10.1016/j.jtcme.2016.06.006

El Kharraf S, El-Guendouz S, Farah A, Bennani B, Mateus MC, El Hadrami EM, Miguel MG (2021). Hydrodistillation and simultaneous hydrodistillation-steam distillation of Rosmarinus officinalis and Origanum compactum: Antioxidant, anti-inflammatory, and antibacterial effect of the essential oils. Industrial Crops and Products168:113591. https://doi.org/10.1016/j.indcrop.2021.113591

EL Moussaoui A, Jawhari FZ, Bourhia M, Maliki I, Sounni F, Mothana RA, Bousta D, Bari A (2020). Withania frutescens: Chemical characterization, analgesic, anti-inflammatory, and healing activities. Open Chemistry 18(1):927-935. https://doi.org/10.1515/chem-2020-0088

Elazzouzi H, Soro A, Elhilali F, Bentayeb A, Belghiti MA, Zair T (2014). Phytochemical study of Anacyclus pyrethrum (L.) of middle atlas (Morocco), and in vitro study of antibacterial activity of pyrethrum. Advances in Natural and Applied Sciences 8(8).

Es-Safi I, Mechchate H, Amaghnouje A, Calarco A, Boukhira S, Noman OM, … Bousta D (2020). Defatted hydroethanolic extract of Ammodaucus leucotrichus Cosson and Durieu seeds: antidiabetic and anti-inflammatory activities. Applied Sciences 10(24):9147. https://doi.org/10.3390/app10249147

Es-Safi I, Mechchate H, Amaghnouje A, Jawhari FZ, Bari A, Cerruti P, … Andriy D (2020). Medicinal plants used to treat acute digestive system problems in the region of Fez-Meknes in Morocco: An ethnopharmacological survey. Ethnobotany Research and Applications 20. https://doi.org/10.32859/era.20.25.1-14

Fadil M, Farah A, Haloui T, Rachiq S (2015). Étude ethnobotanique des plantes exploitées par les coopératives et les associations de la région Meknès-Tafilalet au Maroc. Phytotherapie 13(1):19-30. https://doi.org/10.1007/s10298-014-0902-2

Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE (2007). Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clinical and Experimental Immunology 147(2):227-235. https://doi.org/10.1111/j.1365-2249.2006.03261.x

Fettach S, Mrabti HN, Sayah K, Bouyahya A, Salhi N, Cherrah Y, El Abbes FM (2019). Phenolic content, acute toxicity of Ajuga iva extracts and assessment of their antioxidant and carbohydrate digestive enzyme inhibitory effects. South African Journal of Botany 125:381-385. https://doi.org/10.1016/j.sajb.2019.08.010

Feugang JM, Konarski P, Zou D, Stintzing FC, Zou C (2006). Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Frontiers in Bioscience: A Journal and Virtual Library 11:2574-2589. https://doi.org/10.2741/1992

Gadgoli C, Mishra SH (1999). Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa. Journal of Ethnopharmacology 66(2):187-192. https://doi.org/10.1016/s0378-8741(98)00229-3

Germanò MP, De Pasquale R, D’Angelo V, Catania S, Silvari V, Costa C (2002). Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source. Journal of Agricultural and Food Chemistry 50(5):1168-1171. https://doi.org/10.1021/jf010678d

Ghauri MA, Iqbal L, Raza A, Hayat U, Atif N, Javeed A (2021). In vivo anti-inflammatory, antipyretic, analgesic activity and in vitro anti-proliferative activity of aqueous methanolic extract of Euphorbia granulata Forssk. Future Journal of Pharmaceutical Sciences 7(1):34. https://doi.org/10.1186/s43094-021-00184-9

González-Trujano ME, Peña EI, Martínez AL, Moreno J, Guevara-Fefer P, Déciga-Campos M, López-Muñoz FJ (2007). Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. Journal of Ethnopharmacology, 111(3):476-482. https://doi.org/10.1016/j.jep.2006.12.011

Guimarães AG, Xavier MA, de Santana MT, Camargo EA, Santos CA, Brito FA, … Quintans-Júnior LJ (2012). Carvacrol attenuates mechanical hypernociception and inflammatory response. Naunyn-Schmiedeberg’s Archives of Pharmacology 385(3):253-263. https://doi.org/10.1007/s00210-011-0715-x

Hafsé M, Farah A, Mouktadir JE, Fikri-Benbrahim K (2017). Antioxidant and anti-inflammatory activities evaluation of Coriaria myrtifolia from the North of Morocco. International Food Research Journal 24(2):498-502.

Hmidani A, Bouhlali EDT, Khouya T, Ramchoun M, Filali-Zegzouti Y, Alem C, Benlyas M (2019). Antioxidant, anti-inflammatory and anticoagulant activities of three Thymus species grown in southeastern Morocco. Future Journal of Pharmaceutical Sciences 5(1):1-5. https://doi.org/10.1186/s43094-019-0005-x

Hosseinzadeh S, Kukhdan AJ, Hosseini A, Armand R (2015). The application of Thymus vulgaris in traditional and modern medicine: a review. International Journal of Clinical Medicine 9(3):260-266. https://doi.org/10.5829/idosi.gjp.2015.9.3.94246

Hsoidrou S, Bousta D, Lachkar M, Said Hassane SO, El Youbi-Hamsas A, Mansouri LEL, … Farah A (2014). Phytochemical screening, immunomodulatory and anti-inflammatory activities of the phenolic fraction of Aphloia theiformis (Vahl) Benn. plant used in comorian traditional medicine. Phytothérapie 12(6):354-359. https://doi.org/10.1007/s10298-014-0875-1

Ismaili H, Milella L, Fkih-Tetouani S, Ilidrissi A, Camporese A, Sosa S, … Aquino R (2004). In vivo topical anti-inflammatory and in vitro antioxidant activities of two extracts of Thymus satureioides leaves. Journal of Ethnopharmacology 91(1):31-36. https://doi.org/10.1016/j.jep.2003.11.013

Ismaili H, Sosa S, Brkic D, Fkih-Tetouani S, Ilidrissi A, Touati D, Aquino RP, Tubaro A (2002). Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii. Journal of Pharmacy and Pharmacology 54(8):1137-1140. https://doi.org/10.1211/002235702320266316

Ismaili H, Tortora S, Sosa S, Fkih-Tetouani S, Ilidrissi A, Loggia R Della, Tubaro A, Aquino R (2001). Topical anti-inflammatory activity of Thymus willdenowii. Journal of Pharmacy and Pharmacology 53(12):1645-1652. https://doi.org/10.1211/0022357011778250

Jalayer-Naderi N, Niakan M, Khodadadi E, Mohamadi-Motlagh M (2016). The antibacterial activity of methanolic Anacyclus pyrethrum and Pistacia lentiscus L. extract on Escherichia coli. Iranian Journal of Microbiology 8(6):372-376.

Jamila F, Mostafa E (2014). Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. Journal of Ethnopharmacology 154(1):76-87. https://doi.org/10.1016/j.jep.2014.03.016

Jarić S, Mitrović M, Pavlović P (2015). Review of ethnobotanical, phytochemical, and pharmacological study of Thymus serpyllum L. Evidence-Based Complementary and Alternative Medicine 2015:1-10. https://doi.org/10.1155/2015/101978

Jawhari FZ, El Moussaoui A, Bourhia M, Imtara H, Mechchate H, Es-Safi I, … Bari A (2020). Anacyclus pyrethrum (L): chemical composition, analgesic, anti-inflammatory, and wound healing properties. Molecules (Basel, Switzerland) 25(22). https://doi.org/10.3390/molecules25225469

Kamal R, Kharbach M, Vander Heyden Y, Doukkali Z, Ghchime R, Bouklouze A, Cherrah Y, Alaoui K (2019). In vivo anti‐inflammatory response and bioactive compounds’ profile of polyphenolic extracts from edible Argan oil (Argania spinosa L.), obtained by two extraction methods. Journal of Food Biochemistry 43(12). https://doi.org/10.1111/jfbc.13066

Karadağ AE, Demirci B, Çaşkurlu A, Demirci F, Okur ME, Orak D, Sipahi H, Başer KHC (2019). In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions. South African Journal of Botany 125:214-220. https://doi.org/10.1016/j.sajb.2019.07.039

Kaur M (2012). Pharmacological actions of Opuntia ficus indica: A Review. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/JAPS.2012.2703

Kebbou A, Laaradia MA, Oufquir S, Aarab A, El Gabbas Z, Rais H, Zyad A, Chait A (2019). Antioxidant activity, anti-inflammatory and analgesic effects of Caralluma europaea (Eddaghmouss) in mice. OnLine Journal of Biological Sciences 19(4):272-285. https://doi.org/10.3844/ojbsci.2019.272.285

Khabbal Y, Cadi MA El, Alaoui K, Faouzi MA, Cherrah Y (2006). Activité antiinflammatoire de Zygophyllum gaetulum. Phytothérapie 4(5):227-229. https://doi.org/10.1007/s10298-006-0188-0

Khouya T, Ramchoun M, Amrani S, Harnafi H, Rouis M, Couchie D, Simmet T, Alem C (2020). Anti-inflammatory and anticoagulant effects of polyphenol-rich extracts from Thymus atlanticus: An in vitro and in vivo study. Journal of Ethnopharmacology 252. https://doi.org/10.1016/j.jep.2019.112475

Khouya T, Ramchoun M, Hmidani A, Amrani S, Harnafi H, Benlyas M, Filali Zegzouti Y, Alem C (2015). Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties. Asian Pacific Journal of Tropical Biomedicine, 5(8):636-644. https://doi.org/10.1016/j.apjtb.2015.05.011

Khouya T, Ramchoun M, Hmidani A, Amrani S, Harnafi H, Benlyas M, Zegzouti YF, Alem C (2016). Chemical characterization and evaluation of antioxidant, anti-inflammatory and anticoagulant activity of aqueous extract and organic fractions of Thymus zygis L. sub sp. gracilis. International Journal of Pharmaceutical Sciences and Research 7(4):12. https://doi.org/10.13040/IJPSR.0975-8232.7(4).1396-05

Konstantopoulos K (2005). Editorial hot topic: molecular biology-pathophysiology of inflammation and autoinflammation (Guest Editor: Kostas Konstantopoulos)]. Current Drug Target -Inflammation & Allergy 4(1):39-39. https://doi.org/10.2174/1568010053622849

Lahsissene H, Kahouadji A (2010). Usages thérapeutiques traditionnels des plantes médicinales dans le Maroc occidental: cas de la région de Zaër. Phytothérapie 8(4):210-217. https://doi.org/10.1007/s10298-010-0566-5

Lima M da S, Quintans-Júnior LJ, de Santana WA, Martins Kaneto C, Pereira Soares MB, Villarreal CF (2013). Anti-inflammatory effects of carvacrol: Evidence for a key role of interleukin-10. European Journal of Pharmacology 699(1-3):112-117. https://doi.org/10.1016/j.ejphar.2012.11.040

Lounis H, Bergheim I, Bouhaimi A, Guigonis J-M, Belhamel K (2018). Anti-inflammatory and antioxidant activities of Inula viscosa and Senecio anteuphorbium. Oriental Pharmacy and Experimental Medicine 18(3):225-236. https://doi.org/10.1007/s13596-018-0307-0

Makni M, Haddar A, Kriaa W, Zeghal N (2013). Antioxidant, Free radical scavenging, and antimicrobial activities of Ajuga iva leaf extracts. International Journal of Food Properties 16(4):756-765. https://doi.org/10.1080/10942912.2011.561465

Manouze H, Bouchatta O, Gadhi AC, Bennis M, Sokar Z, Ba-M’hamed S (2017). Anti-inflammatory, antinociceptive, and antioxidant activities of methanol and aqueous extracts of Anacyclus pyrethrum roots. Frontiers in Pharmacology 8(SEP):1-14. https://doi.org/10.3389/fphar.2017.00598

Marmouzi I, Karym EM, Alami R, El Jemli M, Kharbach M, Mamouch F, … Faouzi MEA (2019). Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative and sodium nitroprusside stress and inflammation. Oriental Pharmacy and Experimental Medicine 19(2):201-210. https://doi.org/10.1007/s13596-018-0335-9

Mechchate H, Es-Safi I, Amaghnouje A, Boukhira S, Alotaibi AA, Al-Zharani M, … Bousta D (2021). Antioxidant, anti-inflammatory and antidiabetic proprieties of LC-MS/MS identified polyphenols from coriander seeds. Molecules 26(2). https://doi.org/10.3390/molecules26020487

Merzouki A, Ed-derfoufi F, Molero Mesa J (2000). Contribution to the knowledge of Rifian traditional medicine. II: Folk medicine in Ksar Lakbir district (NW Morocco). Fitoterapia 71(3):278-307. https://doi.org/10.1016/S0367-326X(00)00139-8

Mikou K, Rachiq S, Oulidi AJ, Beniaich G (2015). Étude ethnobotanique des plantes médicinales et aromatiques utilisées dans la ville de Fès au Maroc. Phytothérapie. https://doi.org/10.1007/s10298-015-0965-8

Mohamed Fennane MIT, Oualidi J El (2014). Flore Pratique du Maroc. In: Mohammed V (Ed). Institut Scientifique.

Moher D, Stewart L, Shekelle P (2016). Implementing PRISMA-P: recommendations for prospective authors. Systematic Reviews 5(1):15. https://doi.org/10.1186/s13643-016-0191-y

Moussaid M, Elamrani AE, Bourhim N, Benaissa M (2011). In vivo anti-inflammatory and in vitro antioxidant activities of Moroccan medicinal plants. Natural Product Communications 6(10):1934578X1100601. https://doi.org/10.1177/1934578X1100601007

Moutia M, El Azhary K, Elouaddari A, Al Jahid A, Jamal Eddine J, Seghrouchni F, Habti N, Badou A (2016). Capparis spinosa L. promotes anti-inflammatory response in vitro through the control of cytokine gene expression in human peripheral blood mononuclear cells. BMC Immunology 17(1):1-12. https://doi.org/10.1186/s12865-016-0164-x

Nadeem M, Anjum FM, El-ghorab A (2013). Nutritional and medicinal aspects of coriander (Coriandrum sativum L.) A review. British Food Journal 115(5):743-755. https://doi.org/10.1108/00070701311331526

Najem M, Harouak H, Ibijbijen J, Nassiri L (2020). Oral disorders and ethnobotanical treatments: A field study in the central Middle Atlas (Morocco). Heliyon 6(8):e04707. https://doi.org/10.1016/j.heliyon.2020.e04707

Nematolahi P, Mehrabani M, Karami-Mohajeri S, Dabaghzadeh F (2018). Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial. Complementary Therapies in Clinical Practice 30:24-28. https://doi.org/10.1016/j.ctcp.2017.11.004

Nguemfo EL, Dimo T, Azebaze AGB, Asongalem EA, Alaoui K, Dongmo AB, Cherrah Y, Kamtchouing P (2007). Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). Journal of Ethnopharmacology 114(3):417-424. https://doi.org/10.1016/j.jep.2007.08.022

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, O… Nagai R (2009). CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nature Medicine 15(8):914-920. https://doi.org/10.1038/nm.1964

Ouachrif A, Khalki H, Chaib S, Mountassir M, Aboufatima R, Farouk L, … Chait A (2012). Comparative study of the anti-inflammatory and antinociceptive effects of two varieties of Punica granatum. Pharmaceutical Biology 50(4):429-438. https://doi.org/10.3109/13880209.2011.611142

Ouarghidi A, Martin GJ, Powell B, Esser G, Abbad A (2013). Botanical identification of medicinal roots collected and traded in Morocco and comparison to the existing literature. Journal of Ethnobiology and Ethnomedicine 9(1):1-13. https://doi.org/10.1186/1746-4269-9-59

Oubihi A, Hosni H, Nounah I, Ettouil A, Harhar H, Alaoui K, … Guessous Z (2020). Phenolic content, antioxidant activity, anti-inflammatory potential, and acute toxicity study of Thymus leptobotrys Murb. extracts. Biochemistry Research International 2020:1-7. https://doi.org/10.1155/2020/8823209

Oudghiri M, Azza Z (2015). In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta. Pharmacognosy Research 7(2):213. https://doi.org/10.4103/0974-8490.150510

Pahuja M, Mehla J, Reeta KH, Tripathi M, Gupta YK (2013). Effect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice. Neurochemical Research 38(3):547-556. https://doi.org/10.1007/s11064-012-0947-2

Pahwa R, Goyal A, Bansal P, Jialal I (2021). Chronic Inflammation. In: StatPearls.

Prior RL, Cao G, Martin A, Sofic E, McEwen J, O’Brien C, … Mainland CM (1998). Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. Journal of Agricultural and Food Chemistry 46(7):2686-2693. https://doi.org/10.1021/jf980145d

Ramchoun M, Harnafi H, Alem C, Büchele B, Simmet T, Rouis M, Atmani F, Amrani S (2012). Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties. E-SPEN Journal 7(3):e119-e124. https://doi.org/10.1016/j.clnme.2012.02.005

Ribaldone DG, Pellicano R, Actis GC (2018). Inflammation: a highly conserved, Janus-like phenomenon—a gastroenterologist’ perspective. Journal of Molecular Medicine 96(9):861-871. https://doi.org/10.1007/s00109-018-1668-z

Rimbau V, Cerdan C, Vila R, Iglesias J (1999). Antiinflammatory activity of some extracts from plants used in the traditional medicine of north-African countries (II). Phytotherapy Research: PTR 13(2):128-132. https://doi.org/10.1002/(SICI)1099-1573(199903)13:2<128::AID-PTR399>3.0.CO;2-7

Rodrigo M, Lazaro MJ, Alvarruiz A, Giner V (1992). Composition of capers (Capparis spinosa): Influence of cultivar, size and harvest date. Journal of Food Science 57(5):1152-1154. https://doi.org/10.1111/j.1365-2621.1992.tb11286.x

Rostkowska H, Nowak MJ, Lapinski L, Adamowicz L (1998). Molecular structure and infrared spectra of 2-hydroxy-1,4- naphthoquinone; Experimental matrix isolation and theoretical Hartree–Fock and post Hartree–Fock study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 54(8):1091-1103. https://doi.org/10.1016/S1386-1425(98)00032-8

Saadi B, Msanda F, Boubaker H (2013). Contributions of folk medicine knowledge in South-western Morocco: The case of rural communities of Imouzzer Ida Outanane Region. International Journal of Medicinal Plant Research 2(1):135-145.

Salhi N, Bouyahya A, Fettach S, Zellou A, Cherrah Y (2019). Ethnopharmacological study of medicinal plants used in the treatment of skin burns in occidental Morocco (area of Rabat). South African Journal of Botany 121:128-142. https://doi.org/10.1016/j.sajb.2018.10.038

Saltiel AR, Olefsky JM (2017). Inflammatory mechanisms linking obesity and metabolic disease. The Journal of Clinical Investigation 127(1):1-4. https://doi.org/10.1172/JCI92035

Sayah K, Chemlal L, Marmouzi I, El Jemli M, Cherrah Y, Faouzi MEA (2017). In vivo anti-inflammatory and analgesic activities of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aqueous extracts. South African Journal of Botany 113:160-163. https://doi.org/10.1016/j.sajb.2017.08.015

Shraddha M, Anuradha S (2019). Formulation and evaluation of Emulgel containing Coriandrum sativum seeds oil for anti-inflammatory activity. Journal of Drug Delivery and Therapeutics 9:124-130.

Skalli S, Hassikou R, Arahou M (2019). An ethnobotanical survey of medicinal plants used for diabetes treatment in Rabat, Morocco. Heliyon 5(3):e01421. https://doi.org/10.1016/j.heliyon.2019.e01421

Slighoua M, Mahdi I, Amrati Fez-zahra, Di Cristo F, Amaghnouje A, Grafov A, … Bousta D (2021). Assessment of in vivo estrogenic and anti-inflammatory activities of the hydro-ethanolic extract and polyphenolic fraction of parsley (Petroselinum sativum Hoffm.). Journal of Ethnopharmacology 265:113290. https://doi.org/10.1016/j.jep.2020.113290

Sobeh M, El-Raey M, Rezq S, Abdelfattah MAO, Petruk G, Osman S, El-Shazly AM, … Wink M (2019). Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach. Journal of Ethnopharmacology 240:111939. https://doi.org/10.1016/j.jep.2019.111939

Sobeh M, Rezq S, Sabry OM, Abdelfattah MAO, El Raey MA, El-Kashak WA, … Wink M (2019). Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract. Biomedicine & Pharmacotherapy 115:108882. https://doi.org/10.1016/j.biopha.2019.108882

Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan S, Ravi Prakash V (2001). Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. Journal of Ethnopharmacology 78(2-3):151-157. https://doi.org/10.1016/S0378-8741(01)00333-6

Suzuki K (2019). Chronic inflammation as an immunological abnormality and effectiveness of exercise. Biomolecules 9(6). https://doi.org/10.3390/biom9060223

Taleb-Senouci D, Lacaille-Dubois MA, Bouchenak M (2012). Ajuga iva aqueous extract improves reverse cholesterol transport in streptozotocin-induced diabetic rat. The Journal of Pharmacy and Pharmacology 64(8):1188-1194. https://doi.org/10.1111/j.2042-7158.2012.01501.x

Tlili N, Khaldi A, Triki S, Munné-Bosch S (2010). Phenolic compounds and vitamin antioxidants of caper (Capparis spinosa). Plant Foods for Human Nutrition (Dordrecht, Netherlands) 65(3):260-265. https://doi.org/10.1007/s11130-010-0180-6

Tyagi S, Mansoori MH, Singh NK, Shivhare MK, Bhardwaj P, Singh RK (2011). Antidiabetic effect of Anacyclus pyrethrum DC in alloxan induced diabetic rats. European Journal of Biological Sciences 3(4):117-120.

Zarei M, Seyedi N, Maghsoudi S, Nejad MS, Sheibani H (2021). Green synthesis of Ag nanoparticles on the modified graphene oxide using Capparis spinosa fruit extract for catalytic reduction of organic dyes. Inorganic Chemistry Communications 123:108327. https://doi.org/10.1016/j.inoche.2020.108327

Zekkori B, Khallouki F, Bentayeb A, Fiorito S, Preziuso F, Taddeo VA, Epifano F, Genovese S (2018). A New phytochemical and anti-oxidant and anti-inflammatory activities of different Lactuca sativa L. var. crispa extracts. Natural Product Communications 13(9):1934578X1801300. https://doi.org/10.1177/1934578X1801300910

Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W (1997). Phytotherapy of hypertension and diabetes in oriental Morocco. Journal of Ethnopharmacology 58(1):45-54. https://doi.org/10.1016/S0378-8741(97)00077-9

Zougagh S, Belghiti A, Rochd T, Zerdani I, Mouslim J (2019). Medicinal and Aromatic plants used in traditional treatment of the oral pathology: the ethnobotanical survey in the economic capital Casablanca, Morocco (North Africa). Natural Products and Bioprospecting 9(1):35-48. https://doi.org/10.1007/s13659-018-0194-6

Zouhri A, Aarab L (2018). Ethnobotanical survey of medicinal and aromatic plants used by the people of targuist in the North of Morocco. Der Pharma Chemica 10(5):11-18.

Zouhri A, Bousfiha A, Aarab L (2017). Évaluation des propriétés antioxydantes, anti-inflammatoires et photoprotectrices des lipides de Lawsonia inermis. Phytotherapie 15(2):67-71. https://doi.org/10.1007/s10298-016-1052-5