TY - JOUR AU - ABA, Patrick E. AU - KALU, Marie A. AU - UDEM, Samuel C. PY - 2022/06/06 Y2 - 2024/03/29 TI - Tetrapleura tetraptera ethylacetate pod extract and its biochemical effects on acetaminophen-induced hepatotoxic female rat JF - Notulae Scientia Biologicae JA - Not Sci Biol VL - 14 IS - 2 SE - Research articles DO - 10.55779/nsb14211260 UR - https://notulaebiologicae.ro/index.php/nsb/article/view/11260 SP - 11260 AB - <p>The study investigated the effect of ethyl acetate pod extract of <em>Tetrapleura tetraptera </em>on biochemical markers of liver damage, <em>in vivo</em> and <em>in vitro</em> antioxidant properties using acetaminophen-injured female rats as model. Thirty-five (35) rats assigned into seven groups (A-G) of five rats per group were used for the study. Rats in groups C, D, E and F were pretreated with 100, 200, 400 and 200 mg/kg of the extract while group G rats received Silymarin (100 mg/kg). Distilled water (10 ml/kg) was administered to groups A and B rats. All pretreatments were via the oral route and lasted for seven days. Following pretreatments, acetaminophen (2000 mg/kg) was used to induce liver injury in groups B, C, D, E and G while rats in group A served as normal control. Blood samples were collected 48 h post acetaminophen administration for analyses of the following parameters: Alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum bilirubin, reduced glutathione and superoxide dismutase. Liver tissues were collected for histopathology studies. <em>In vitro</em> antioxidant profile of the extract was evaluated. Results indicated decreases in the activities of ALT and ALP of the extract-treated groups compared to the negative control group. The liver section of the rats treated with 400 mg/kg of the extract showed no lesions and was comparable to that of the normal control rats. The <em>in vivo</em> and <em>in vitro</em> antioxidant activities were in dose and concentration-dependent manner respectively. It was concluded that <em>Tetrapleura tetraptera </em>ethyl acetate extract possesses both hepatoprotective and antioxidant properties.</p> ER -