@article{PANCHANATHAN_RAJENDRAN_2015, title={Evidence of Anti-hyperglycemic and Anti-oxidant Effect of Passiflora edulis flavicarpa (Sims.) in Streptozotocin Induced Diabetic Rats}, volume={7}, url={https://notulaebiologicae.ro/index.php/nsb/article/view/9655}, DOI={10.15835/nsb749655}, abstractNote={<p style="text-align: justify;">Diabetes mellitus is a worldwide problem and has no distinct cure. The present study was designed to investigate the antidiabetic, antioxidant and antilipidemic effects of <em>Passiflora edulis flavicarpa</em> extract (PefEt) against streptozotocin (STZ) induced diabetic rats. A total of forty wistar rats were randomly divided into four groups (n = 10 male rats/group) as control; control+PefEt; diabetic and diabetic + PefEt. Streptozotocin was administered as a single dose (50 mg/kg) to induce diabetes. The effect of <em>Passiflora edulis flavicarpa</em> (PefEt-250 mg/kg bodyweight for four weeks) on diabetic rats was investigated by evaluating various biochemical parameters. The levels of blood glucose, C-peptide, insulin; enzymatic antioxidants, total antioxidant status, oxidative markers (Malondialdehyde and Urinary 8-hydroxydeoxyguanosine) and lipid profile were measured. Levels of glucose, MDA and urinary 8-OHdG were significantly decreased, while levels of antioxidants, C-peptide and insulin were significantly increased on administration of PefEt in the STZ-induced rats when compared to control groups. Therefore, it could be concluded that PefEt must be considered as an excellent herb for future studies on diabetes mellitus.</p>}, number={4}, journal={Notulae Scientia Biologicae}, author={PANCHANATHAN, Subash and RAJENDRAN, Jayanthi}, year={2015}, month={Dec.}, pages={383–389} }