@article{ABA_KALU_UDEM_2022, title={Tetrapleura tetraptera ethylacetate pod extract and its biochemical effects on acetaminophen-induced hepatotoxic female rat}, volume={14}, url={https://notulaebiologicae.ro/index.php/nsb/article/view/11260}, DOI={10.55779/nsb14211260}, abstractNote={<p>The study investigated the effect of ethyl acetate pod extract of <em>Tetrapleura tetraptera </em>on biochemical markers of liver damage, <em>in vivo</em> and <em>in vitro</em> antioxidant properties using acetaminophen-injured female rats as model. Thirty-five (35) rats assigned into seven groups (A-G) of five rats per group were used for the study. Rats in groups C, D, E and F were pretreated with 100, 200, 400 and 200 mg/kg of the extract while group G rats received Silymarin (100 mg/kg). Distilled water (10 ml/kg) was administered to groups A and B rats. All pretreatments were via the oral route and lasted for seven days. Following pretreatments, acetaminophen (2000 mg/kg) was used to induce liver injury in groups B, C, D, E and G while rats in group A served as normal control. Blood samples were collected 48 h post acetaminophen administration for analyses of the following parameters: Alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum bilirubin, reduced glutathione and superoxide dismutase. Liver tissues were collected for histopathology studies. <em>In vitro</em> antioxidant profile of the extract was evaluated. Results indicated decreases in the activities of ALT and ALP of the extract-treated groups compared to the negative control group. The liver section of the rats treated with 400 mg/kg of the extract showed no lesions and was comparable to that of the normal control rats. The <em>in vivo</em> and <em>in vitro</em> antioxidant activities were in dose and concentration-dependent manner respectively. It was concluded that <em>Tetrapleura tetraptera </em>ethyl acetate extract possesses both hepatoprotective and antioxidant properties.</p>}, number={2}, journal={Notulae Scientia Biologicae}, author={ABA, Patrick E. and KALU, Marie A. and UDEM, Samuel C.}, year={2022}, month={Jun.}, pages={11260} }