@article{DANDAPAT_KUMAR_RANJAN_SINHA_2019, title={Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat}, volume={11}, url={https://notulaebiologicae.ro/index.php/nsb/article/view/10473}, DOI={10.15835/nsb11310473}, abstractNote={<p style="text-align: justify;"><em>Ganoderm applanatum </em>is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by <em>G. applanatum </em>extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanoparticles were of average 58.78 nm in diameter with -13.8 mV zetpotential, analysed by dynamic light scattering method. Fourier transform infrared spectroscopy analysis of synthesized nanoparticles confirmed the capping and stabilizing with mycochemicals, that showed transmittance at   3606 cm<sup>-1</sup> corresponds to O-H stretch for phenol, 2430 cm<sup>-1</sup> corresponds to N-H stretch for primary and secondary amines. 2000 mg kg<sup>-1</sup>, 200 mg kg<sup>-1</sup> and 400 mg kg<sup>-1</sup> doses of silver nanoparticles showed non-significant (p<0.05) increase in body weight and organ weight. Non-significant increase in RBC indices were observed and significant (p<0.05) increase in WBC count (7.28±0.41 × 10<sup>3 </sup>µL<sup>-1 </sup>and 8.41±0.35 × 10<sup>3 </sup>µL<sup>-1</sup>) at 200 mg kg<sup>-1</sup> and 400 mg kg<sup>-1</sup> doses of silver nanoparticles  were observed. Thus, <em>G. applanatum </em>extract mediated silver nanoparticles can be used pharmacologically and medicinally due to their nontoxic effect.</p>}, number={3}, journal={Notulae Scientia Biologicae}, author={DANDAPAT, Sukumar and KUMAR, Manoj and RANJAN, Rakesh and SINHA, Manoranjan P.}, year={2019}, month={Sep.}, pages={351–363} }