Evaluation of Antiaggressive Activity of Capparis zeylanica Root Extract in Experimental Animal Model

  • Sunil Kumar MISHRA Indian Institute of Technology (BHU), Varanasi 221 005 (IN)
  • Paras Nath SINGH Indian Institute of Technology (BHU), Varanasi 221 005 (IN)
  • Satya Deo DUBEY Institute of Medical Science (BHU), Varanasi 221 005 (IN)

Abstract

Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma-aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100, 200 and 400 mg/kg of ethanolic extract of Capparis zeylanica root (EECZ) circumvent aggression. Foot shock induced aggression, isolation-induced aggression, resident-intruder aggression and water competition test were utilized as models for screening of antiaggressive activity. Extract was given orally at three different dose levels (100, 200 and 400 mg/kg) once daily for three consecutive days, while Diazepam (2.5 mg/kg), was administered as positive control. EECZ significantly (p<0.05) minimized aggression dose dependently in the entire dose (100, 200, 400 mg/kg). Results suggested that EECZ showed significant antiagressive activity in aforementioned validated models of aggression. EECZ at all dose levels (100, 200 and 400 mg/kg) have shown promising anti-aggressive activity qualitatively comparable to that of diazepam (2.5 mg/kg).

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Author Biography

Sunil Kumar MISHRA, Indian Institute of Technology (BHU), Varanasi 221 005
Pharmaceutics
Published
2013-05-28
How to Cite
MISHRA, S. K., SINGH, P. N., & DUBEY, S. D. (2013). Evaluation of Antiaggressive Activity of Capparis zeylanica Root Extract in Experimental Animal Model. Notulae Scientia Biologicae, 5(2), 127-132. https://doi.org/10.15835/nsb528932
Section
Research articles
CITATION
DOI: 10.15835/nsb528932