In vitro anti-urease, antioxidant, anticholinesterase, cytotoxic and in vivo anti-inflammatory potential of Satureja cuneifolia Ten.
DOI:
https://doi.org/10.15835/nsb12210687Keywords:
anti-urease; anticholinesterase; anti-inflammatory; cytotoxic; S. cuneifoliaAbstract
Satureja cuneifolia Ten. (wild savoury) belongs to the Lamiaceae family and is used to produce essential oil and aromatic water. This plant is also used as a condiment and herbal tea due to its stimulating, tonic and carminative effects. The in vitro antioxidant, anti-urease, anticholinesterase and cytotoxic activities of the different extracts from the plant’s aerial parts were examined. Besides, the in vivo anti-inflammatory activities of the fraction and direct methanol extracts were determined comparatively. In the current study, fraction methanol extract exhibited the strongest ABTS (52.34 mM trolox/mg extract) radical scavenging and ferric reduction (17.22 mM Fe2+/mg extract) activity. It was also found that the fraction methanol extract had stronger anti-urease (12.52%) and anticholinesterase (69.02%) activity than other extracts. The XTT results showed that fraction methanol extract had the most cytotoxic activity on MCF-7 cell lines (39.92%). According to the results of in vivo anti-inflammatory activity, it was found that both fraction and direct methanol extracts exhibited close and significant anti-inflammatory activity. The fact that methanol extracts have significant biological activity suggests that these may be used as a natural source in the future.
Metrics
References
Amanlou M, Dadkhah F, Salehnia A, Farsam H, Dehpour AR (2005). An anti-inflammatory and anti- nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. Journal of Pharmacy and Pharmaceutical Sciences 8(1):102-106. https://pubmed.ncbi.nlm.nih.gov/15946603/
Ayoub Z, Mehta A, Mishra SK, Ahirwal L (2017). Medicinal plants as natural antioxidants: A review. Journal of Botanical Society 48:1-9. https://www.researchgate.net/publication/327573857
Benzie IF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry 239(1):70-76. https://doi.org/10.1006/abio.1996.0292
Bezi N, SkoIbu M, Jaunk V (2005). Phytochemical composition and antimicrobial activity of Satureja montana L. and Satureja cuneifolia Ten. essential oils. Acta Botanica Croatica 64(2):313-322. https://hrcak.srce.hr/3352
Butterfield DA, Halliwell B (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience 20(3):148-160. https://dx.doi.org/10.1038/s41583-019-0132-6
Ellman GL, Courtney KD, Andres Jr V, Featherstone RM (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7(2):88-90. https://doi.org/10.1016/0006-2952(61)90145-9
Fang YZ, Yang S, Wu G (2002). Free radicals, antioxidants and nutrition. Nutrition 18(10):872-879.
https://doi.org/10.1016/S0899-9007(02)00916-4
García-Rellána D, Verdeguer M, Salamone A, Amparo Blázquez M, Boira H (2016). Chemical composition, herbicidal and antifungal activity of Satureja cuneifolia essential oils from Spain. Natural Product Communications 11(6):841-844. https://pubmed.ncbi.nlm.nih.gov/27534131/
Hajhashemi V, Zolfaghari B, Yousefi A (2012). Antinociceptive and anti-inflammatory activities of Satureja hortensis seed essential oil, hydroalcoholic and polyphenolic extracts in animal models. Medical Principles and Practice 21(2):178-182. https://doi.org/10.1159/000333555
Hanif M, Shoaib K, Saleem M, Rama NH, Zaib S, Iqbal J (2012). Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives. International Scholarly Research Network Pharmacology 2012:1-9. https://doi.org/10.5402/2012/928901
Henstridge CM, Hyman BT, Spires-Jones TL (2019). Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis. Nature Reviews Neuroscience 20(2):94-108. https://doi.org/10.1038/s41583-018-0113-1
Holleczek B, Schöttker B, Brenner H (2020). Helicobacter pylori infection, chronic atrophic gastritis and risk of stomach and oesophagus cancer: results from the prospective population‐based esther cohort study. International Journal of Cancer 146:2773-2783. https://doi.org/10.1002/ijc.32610
Jafari F, Ghavidel F, Zarshenas MM (2016). A Critical overview on the pharmacological and clinical aspects of popular Satureja species. Journal of Acupuncture and Meridian Studies 9(3):118-127. https://doi.org/10.1016/j.jams.2016.04.003
Kindl M, Blažeković, B, Bucar F, Vladimir-Knežević S (2015). Antioxidant and anticholinesterase potential of six Thymus Species. Evidence-Based Complementary and Alternative Medicine 2015:1-10. http://dx.doi.org/10.1155/2015/403950
Long JM, Holtzman DM (2019). Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179(2):312-339. https://doi.org/10.1016/j.cell.2019.09.001
Mimica-Dukić N, Simin N, Orčić D, Lesjak M, Knežević P, Aleksić V, Buzas K (2018). Therapeutic efficiency of essential oils against Helicobacter pylori infections. Facta Universitatis, Series Physics, Chemistry and Technology 16(1):29-32. http://casopisi.junis.ni.ac.rs/index.php/FUPhysChemTech/
Mogana R, Adhikari A, Debnath S, Hazra S, Hazra B, Teng-Jin K, Wiart C (2014). The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq., BioMed Research International 2014:1-7. http://dx.doi.org/10.1155/2014/903529
Oke F, Aslim B, Ozturk S, Altundag S (2009). Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten. Food Chemistry 112(4):874-879. https://doi.org/10.1016/j.foodchem.2008.06.061
Ozsoy N, Can A, Yanardağ R, Akev N (2008). Antioxidant activity of Smilax excels L. leaf extracts. Food Chemistry 110(3):571-583. https://doi.org/10.1016/j.foodchem.2008.02.037
Ramos‐Tovar E, Muriel P (2020). Free Radicals, Antioxidants, nuclear factor‐e2‐related factor‐2 and liver damage. Journal of Applied Toxicology 40(1):151-168 https://doi.org/10.1002/jat.3880
Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999). Antioxidant activity applying an improved abts radical cation decolorization assay. Free Radical Biology and Medicine 26(9-10):1231-1237. https://doi.org/10.1016/S0891-5849(98)00315-3
Sadeghi I, Yousefzadi M, Behmanesh M, Sharifi M, Moradi A (2013). In vitro cytotoxic and antimicrobial activity of essential oil from Satureja intermedia. Iranian Red Crescent Medical Journal 15(1):70-74. https://pubmed.ncbi.nlm.nih.gov/23487431/
Taskin T, Çam ME, Taşkın D, Rayaman E (2019). In vitro and In vivo biological activities and phenolic characterization of Thymus praecox subsp. skorpilii var. skorpilii. Journal of Food Measurement and Characterization 13:536-544. https://doi.org/10.1007/s11694-018-9967-1
Taslimi P, Kokksal E, Goren AC, Bursal E, Aras A, Kılıc O, Alwasel S, Gulçin I (2020). Anti-Alzheimer, antidiabetic and antioxidant potential of Satureja cuneifolia and analysis of its phenolic contents by LC-MS/MS. Arabian Journal of Chemistry 13(3):4528-4537. https://doi.org/10.1016/j.arabjc.2019.10.002
Taşkın D, Taşkın T, Rayaman E (2018). Phenolic composition and biological properties of Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Industrial Crops and Products 111:555-562 https://doi.org/10.1016/j.indcrop.2017.11.022
Tepe B, Cilkiz M (2015). A pharmacological and phytochemical overview on Satureja. Pharmaceutical Biology 54(3):375-412. https://doi.org/10.3109/13880209.2015.1043560
Vazquez E, Navarro M, Salazar Y, Crespo G, Bruges G, Osorio C, … Lopez M (2015). Systemic changes following carrageenan-induced paw inflammation in rats. Inflammation Research 64:333-342. https://doi.org/10.1007/s00011-015-0814-0.
Wolf NB, Küchler S, Radowski MR, Blaschke T, Kramer KD, Weindi G (2009). Influences of opioids and nanoparticles on in vitro wound healing models. European Journal of Pharmaceutics and Biopharmaceutics 73(1):34-42. https://doi.org/10.1016/j.ejpb.2009.03.009
Yousefzadi M, Riahi-Madvar A, Hadian J, Rezaee F, Rafiee R (2012). In vitro cytotoxic and antimicrobial activity of essential oil from Satureja sahendica. Toxicological and Environmental Chemistry 94(9):1735-1745. https://doi.org/10.1080/02772248.2012.728606
Downloads
Published
How to Cite
Issue
Section
License
Papers published in Notulae Scientia Biologicae are Open-Access, distributed under the terms and conditions of the Creative Commons Attribution License.
© Articles by the authors; licensee SMTCT, Cluj-Napoca, Romania. The journal allows the author(s) to hold the copyright/to retain publishing rights without restriction.
License:
Open Access Journal - the journal offers free, immediate, and unrestricted access to peer-reviewed research and scholarly work, due SMTCT supports to increase the visibility, accessibility and reputation of the researchers, regardless of geography and their budgets. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author.
.png)
