In vitro anti-urease, antioxidant, anticholinesterase, cytotoxic and in vivo anti-inflammatory potential of Satureja cuneifolia Ten.

  • Turgut TASKIN University of Marmara, Faculty of Pharmacy, 34668, Istanbul
  • Murat DOGAN University of Sivas Cumhuriyet, Faculty of Pharmacy, Sivas
  • Muhammet E. CAM University of Marmara, Faculty of Pharmacy, 34668, Istanbul; Center for Nanotechnology and Biomaterials Application and Research (NBUAM); University College London, Department of Mechanical Engineering, Torrington Place, London WC1E 7JE
  • Talip SAHIN University of Marmara, Faculty of Pharmacy, 34668, Istanbul
  • Ismail SENKARDES University of Marmara, Faculty of Pharmacy, 34668, Istanbul
Keywords: anti-urease; anticholinesterase; anti-inflammatory; cytotoxic; S. cuneifolia

Abstract

Satureja cuneifolia Ten. (wild savoury) belongs to the Lamiaceae family and is used to produce essential oil and aromatic water. This plant is also used as a condiment and herbal tea due to its stimulating, tonic and carminative effects. The in vitro antioxidant, anti-urease, anticholinesterase and cytotoxic activities of the different extracts from the plant’s aerial parts were examined. Besides, the in vivo anti-inflammatory activities of the fraction and direct methanol extracts were determined comparatively. In the current study, fraction methanol extract exhibited the strongest ABTS (52.34 mM trolox/mg extract) radical scavenging and ferric reduction (17.22 mM Fe2+/mg extract) activity. It was also found that the fraction methanol extract had stronger anti-urease (12.52%) and anticholinesterase (69.02%) activity than other extracts.  The XTT results showed that fraction methanol extract had the most cytotoxic activity on MCF-7 cell lines (39.92%).  According to the results of in vivo anti-inflammatory activity, it was found that both fraction and direct methanol extracts exhibited close and significant anti-inflammatory activity. The fact that methanol extracts have significant biological activity suggests that these may be used as a natural source in the future.

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Published
2020-06-29
How to Cite
TASKIN, T., DOGAN, M., CAM, M. E., SAHIN, T., & SENKARDES, I. (2020). In vitro anti-urease, antioxidant, anticholinesterase, cytotoxic and in vivo anti-inflammatory potential of Satureja cuneifolia Ten. Notulae Scientia Biologicae, 12(2), 222-232. https://doi.org/10.15835/nsb12210687
Section
Research articles